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March 2020  
 
Chemical updates made to the ITER database  
 
January 2020 
 
ITER Database moves to http:s://iter.tera.org  

ITER is currently available https://iter.tera.org  
 
Searching the “Original ITER” Database  
 
To search the “Original ITER” database, go to www.tera.org/iter and click on Search Original ITER. Enter a chemical name, portion of a name, or CAS number. (NOTE: CAS numbers are the most effective way to search because it avoids the confusion about which chemical name is being used). You can also select from a list of all chemicals. When your search results have been returned, you can view the chemical data online or you can generate and print a report for a chemical. 
 
What's included on ITER? 
ITER contains data from national and international organizations worldwide. ITER provides links to these organizations for more detailed information. ITER currently contains data from:  
 
Agency for Toxic Substances and Disease Registry (ATSDR)  
ATSDR derives minimal risk levels (MRLs), which are found in the Agency's Toxicological Profiles.  
 
Health Canada  
Health Canada develops Tolerable Intakes/Concentrations and Tumorigenic Doses/Concentrations for Priority Substances under the Canadian Environmental Protection Act (CEPA). These risk values for Health Canada are included on ITER. 
 
International Agency for Research on Cancer (IARC) 
We are currently adding IARC's data to ITER. Look for announcements about this on ITER’s “What’s New” page.  
IARC evaluates the cancer weight of evidence for chemicals over a wide range of human exposures and classifies chemicals according to potential for carcinogenicity. The results of IARC analyses are published Monographs. IARC cancer classification groups and detailed descriptions of these groups can be found in the Preamble to each monograph and at http://monographs.iarc.fr/ENG/Preamble/index.php The IARC evaluation considers the evidence of carcinogenicity in humans, the evidence of carcinogenicity in experimental animals, and other data relevant to the evaluation of carcinogenicity and its mechanisms.  
 
NSF International  
 
NSF International, an independent, not-for-profit organization, derives action levels [the total allowable concentration (TAC), single product allowable concentration (SPAC), and short-term exposure level (STEL)] for contaminants detected in laboratory testing of products in contact with drinking water and food. The basis for the action levels is the oral reference dose (RfD) for non-cancer risk assessment and the appropriate risk level for carcinogen risk assessment. U.S. EPA non-cancer and cancer risk assessment procedures are followed and a risk assessment document is prepared.  
 
National Institute of Public Health and the Environment (RIVM), The Netherlands  
RIVM develops human-toxicological risk limits (i.e., maximum permissible risk levels, MPRs) for a variety of chemicals based on chemical assessments that are compiled in the framework of the Dutch government program on risks in relation to soil quality. The MPRs updated in 2001 have been added to ITER.  
 
Texas Commission on Environmental Quality (TCEQ) 
 
TCEQ derives risk values called Effects Screening Levels (ESLs), inhalation Reference Values (ReVs), and inhalation Unit Risk Factors (URFs), which are published in Development Support Documents (DSDs). DSDs summarize how chemical-specific toxicity values were derived based on published guidelines (RG-442, TCEQ Guidelines to Develop Toxicity Factors).  
 
U.S. Environmental Protection Agency (EPA )  
 
EPA derives risk values called reference concentrations (RfCs), reference doses (RfDs) and cancer assessments. All of these risk values from EPA’s Integrated Risk Information System (IRIS) are included on ITER.  
 
Independent parties whose risk values have undergone peer review  
 
Risk values developed by other parties (e.g. industry, consulting groups, government, universities, etc.) that do not meet the criteria for having their own column on ITER (such as having data for at least 40 chemicals) are included on ITER under the ITER PR column or the IPRV column after they have undergone an independent peer review.  
 
ITER PR Column 
The ITER PR column contains data from those organizations whose risk values have undergone peer review through TERA’s ITER Peer Review process (https://tera.org/Peer). This independent peer review is convened by TERA through its Peer Review Program, and if the expert panel concurs with an assessment, it can be made available to the public on the ITER database. Over two-dozen independent risk values have been included in the ITER PR column. Most of the independent values can only be found on ITER.  
 
IPRV Column 
The IPRV column contains data from those organizations that do not meet the criteria for having their own column (such as having data for at least 40 chemicals) and whose risk values have undergone peer review outside TERA’s ITER Peer Review process.  
 
 
Risk values are principally used as guidance or regulatory levels against which human exposures from contamination of air, food, soil, and water can be compared. The information on ITER is useful to risk assessors and risk managers needing human health risk values to make risk-based decisions. ITER allows the user to compare a number of key organizations' values and to determine the best value to use for the human exposure situation being evaluated. 

If you would like to view the data for a chemical, click on its chemical name. This will take you to the Level 1 table for that chemical, which contains red and gray circles for each organization and category (noncancer oral, cancer oral, noncancer inhalation, or cancer inhalation). The red circles indicate that ITER contains data, and the gray circles indicate that ITER does not contain data for that particular organization or category. (Note: In some cases the organization may have data available but it has not yet been prepared for inclusion in ITER. See the above section, entitled “What is ITER” to determine which organizations’ data is currently being added to ITER). Click on the red circles to go to the Level 2 table, which displays the key elements for each organization’s risk value along with a synopsis explaining any differences among risk values. At the bottom of the Level 2 table, you can click on the green circle(s) to go to Level 3 and obtain more information about a particular organization’s risk value (including a source and/or link for further information about that particular assessment).
If you want to generate and print a report, click on print
January 2016  
 
 
We recently added/updated cancer classifications from IARC for Benzidine, Benz[a]anthracene, Benzo[a]pyrene, Butyl Benzyl Phthalate (BPP), Captafol, Chlordecone (Kepone), Chlorothalonil, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), Thiourea, Vinyl Chloride, The ITER entries for these chemicals are based on the IARC Monographs, and include a link to the Monographs.  

November 2015 
 
ATSDR published Draft for Public Comment Toxicological Profiles for DEET and Toluene (Update). The ITER entries for DEET and Toluene, have been updated based on the Toxicological Profiles. DEET is a new addition to ITER. 
ATSDR published final Toxicological Profiles for 1,1-Dichloroethane, Endosulfan, and Hexachlorobenzene. The ITER entries for 1,1-Dichloroethane, Endosulfan, and Hexachlorobenzene, have been updated based on the Toxicological Profiles. 
ATSDR published Draft for Public Comment Toxicological Profiles for DEET and Toluene (Update). The ITER entries for DEET and Toluene, have been updated based on the Toxicological Profiles. DEET is a new addition to ITER. 

July 2015 
 
We recently added/updated cancer classifications from IARC for Indeno[1,2,3-cd]pyrene, Mirex, N-Nitroso-di-n-butylamine, N-Nitrosodiethylamine, N-nitrosodimethylamine (NDMA), N-Nitrosodiphenylamine, N-Nitrosodi-N-propylamine, N-Nitroso-N-methylethylamine, N-Nitrosopyrrolidine, Pentachloronitrobenzene (Quintozene), Phenol, m-Phenylenediamine, Propham, Quinone (1,4-Benzoquinone), Selenium and compounds, Sodium diethyldithiocarbamate, and Zineb, The ITER entries for these chemicals are based on the IARC Monographs, and include a link to the Monographs. 
 
June 2015  
 
We recently added/updated cancer classifications from IARC for Bromomethane (Methyl bromide), 1,4-Dihydroxybenzene (Hydroquinone), Dimethylaniline, N-N-, Methyl acrylate, Methyl Chloride (Chloromethane), Methyl Methacrylate, Methyl Parathion, Naphthalene, Nitrobenzene, N-Nitrosodiethanolamine, Permethrin, Toluene, and Xylenes. The ITER entries for these chemicals are based on the IARC Monographs, and include a link to the Monographs. 
 
May 2015  
 
We recently added/updated cancer classifications from IARC for Acenaphthene, Acrolein, Acrylic Acid, Aldicarb, Allyl Chloride, Aniline, Benzofuran, 2,3-, 2-Butoxyethanol (EGBE), Creosote, Dibenz[a,h]anthracene, Dichlorobenzene, 1,2-, Dichlorobenzene, 1,3-, Diethanolamine, Dimethylhydrazine, 1,2-, Furfural (2-Furaldehyde), gamma-Butyrolactone, Heptachlor, Hexachlorobutadiene, Hydrochloric Acid, Monochloramine, Chrysene, Fluoranthene, Fluorene, Phenanthrene, Pyrene, Refractory ceramic fibers, Sodium Chlorite, Triethanolamine, Tris-(2-chloroethyl) Phosphate (TCEP), and Vanadium Pentoxide. The ITER entries for these chemicals are based on the IARC Monographs, and include a link to the Monographs. 
 
 
February 2015  
 
We recently added an Independently Peer Reviewed Cancer Oral assessment for 1-4, Dioxane based on an assessment conducted by Dourson et al., 2014. 
October 2014 
 
We recently added/updated IARC cancer classifications for 1,1,1,2-tetrachloroethane, 1,1,2,2-tetrachloroethane, chloral, chloral hydrate, dichloroacetic acid, tetrachloroethylene, trichloroacetic acid, and trichloroethylene. 
 
 
August 29, 2014 
 
We recently added inhalation risk data from TCEQ (Texas Commission on Environmental Quality) for Chromium (VI), Hexavalent. TCEQ’s data for this chemical is based on TCEQ’s Development Support Documents (DSD) for Hexavalent Chromium.  
 
 
May 31, 2014 
 
ATSDR published updated Toxicological Profiles for Phosphate Ester Flame Retardants. The ITER entries for Tri-(2-chloroisopropyl) phosphate (TCPP), Tricresyl phosphate (TCP), Tributoxyethyl phosphate (TBEP), Tributyl phosphate (TnBP), Triisobutyl phosphate (TiBP), Triphenyl Phosphate (TPP), Tris(1,3-dichloro-2-propyl) Phosphate (TDCP), Tris-(2-chloroethyl) Phosphate (TCEP) have been updated based on the Toxicological Profile. 

May 24, 2013  
 
We recently began adding IPCS data to ITER. We added data for the following chemicals: Acrylonitrile, Barium, Beryllium and compounds, 2-Butoxyethanol (EGBE), Calcium cyanide, Chlorine Dioxide, Cobalt, Cyanogen, Cyanogen Chloride (Chlorine Cyanide), Dibutyltin Dichloride, 3,3'-Dichlorobenzidine, 1,2-Dichloroethane, 1,1-Dichloroethylene (Vinylidene Chloride), Dimethyltin Dichloride (DMTC), Dioctyltin dichloride (DOTC), 2-Ethoxyethanol, Ethylene Glycol, Monomethyltin Trichloride (MMTC), Monooctyltin Trichloride (MOTC), N-nitrosodimethylamine (NDMA), Potassium cyanide, 2-Propoxyethanol, Sodium cyanide, Tetrachloroethane, 1,1,2,2-, Tetrafluoroethane, 1,1,1,2-, Triglycidyl isocyanurate, and Triphenyltin (TPT). The ITER entries for these chemicals are based on the IPCS CICAD documents. Dimethyltin Dichloride (DMTC), Dioctyltin dichloride (DOTC), Monomethyltin Trichloride (MMTC), Monooctyltin Trichloride (MOTC), 2-Propoxyethanol, and Triglycidyl isocyanurate are new additions to ITER. 
 
 
ATSDR published updated Toxicological Profiles for Acrylamide. The ITER entries for Acrylamide have been updated based on the Toxicological Profiles. 
 
 
April 30, 2013 
 
We recently added data from NSF International for Nadic Methyl Anhydride (class based evaluation). The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of the document as well as a link to purchase the full report. Nadic Methyl Anhydride (class based evaluation) is a new addition to ITER. 
 
ATSDR published updated Toxicological Profiles for 1,3-Butadiene, Chromium(VI), Manganese, and Uranium. The ITER entries for 1,3-Butadiene, Chromium(VI), Hexavalent, Manganese, Uranium, and Uranium, soluble salts have been updated based on the Toxicological Profiles. 
 
We recently began adding IPCS data to ITER. We added data for the following chemicals: Benzoic acid, 1,1-Biphenyl, 1,3-Butadiene, Diethyl Phthalate (DEP), 1,3-Dihydroxybenzene (Resorcinol), Methyl Chloride (Chloromethane), N,N- Dimethylformamide, N-Phenyl-1-naphthylamine, o-Toluidine, Polychlorinated Biphenyls (PCBs), Thiourea, Tin, Inorganic, and Tributyltin Oxide (TBTO). The ITER entries for these chemicals are based on the IPCS CICAD documents. N-Phenyl-1-naphthylamine and Thiourea are new additions to ITER. 
 
 
March 11, 2013 
 
We recently began adding IPCS data to ITER. We added data for the following chemicals: Arsine, Bromoethane, Creosote, Formaldehyde, Heptachlor, Hydrogen Sulfide, Iodine, Isobutyl acetate, Methyl Methacrylate, n-Butyl Acetate, n-Methyl-2-pyrrolidone, Phenylhydrazine, Potassium iodide, sec-Butyl acetate, Sodium iodide, and tert-Butyl acetate. The ITER entries for these chemicals are based on the IPCS CICAD documents. Bromoethane, Isobutyl acetate, n-Methyl-2-pyrrolidone, Phenylhydrazine, sec-Butyl acetate, and tert-Butyl acetate are new additions to ITER. 
 
Februrary 1, 2013 
 
We recently added data from NSF International for Bromide. The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of the document as well as a link to purchase the full report. Bromide is a new addition to ITER. 
 
We recently began adding IPCS data to ITER. We added data for the following chemicals: 2,2-dichloro 111 triflouroethane (HCFC-123), Aroclor 1254, Asphalt (Bitumen), Butyl benzyl phthalate (BBP), Crotonaldehyde (2-Butenal), d-Limonene, Ethyl Cyanoacrylate (ECA), Ethylene diamine, Ethylene Oxide, Furfural (2-Furaldehyde), Glyoxal, Hydrogen Cyanide, Maleic Anhydride, Manganese, Mercuric Chloride (Mercury, inorganic), Mercury, elemental, Methyl Cyanoacrylate (MCA), Methylene diphenyl diisocyanate (MDI), p-Chloroaniline (para-Chloroaniline), p-Nitrophenol (4-Nitrophenol), Phthalic anhydride, Strontium, Vanadium, and Vanadium Pentoxide. The ITER entries for these chemicals are based on the IPCS CICAD documents. 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123), Asphalt (Bitumen), Ethyl Cyanoacrylate (ECA), Glyoxal, Methyl Cyanoacrylate (MCA) are new additions to ITER. 

December 31, 2012 
 
We recently began adding IPCS data to ITER. We added data for the following chemicals: Acrolein, Aroclor 1016, Aroclor 1248, Azodicarbonamide, Carbon Disulfide, Chloral Hydrate, Chloroform, Cumene, Diethylene glycol dimethyl ether, and 1,2,3 - Trichloropropane. The ITER entries for these chemicals are based on the IPCS CICAD documents. Azodicarbonamide and Diethylene glycol dimethyl ether are new additions to ITER. 
 
TERA recently completed its third meeting of the ITER Review Program – ITERate – through which TERA convened a panel of experts to evaluate the basis and derivation of risk values published in peer reviewed manuscripts and to determine whether it is appropriate to load onto ITER. The third meeting resulted in loading the following data to ITER under the ITER PR column: Chromium (VI), Hexavalent (cancer inhalation data from Crump et al., 2003). Details about this review process and the meeting report can be found at https://tera.org/Peer/ITERReview/index.html.  
 
We recently added data from NSF International for Hydrogen Peroxide. The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of the document as well as a link to purchase the full report. Hydrogen Peroxide is a new addition to ITER. 
 
ATSDR published updated Toxicological Profiles for 1,4-Dioxane, Carbon Monoxide, and Radon 222. The ITER entries for have been updated for 1,4-Dioxane, Carbon Monoxide, and Radon 222 based on the Toxicological Profiles. 
 
 
August 31, 2012 
 
NEW COLUMN ADDED! TCEQ Risk Values now on ITER 
 
We recently added a new column to ITER, entitled “TCEQ – Texas Commission on Environmental Quality”. This column contains data from the Texas Commission on Environmental Quality. We recently added inhalation risk data from TCEQ for Nickel Chloride and Arsenic, Inorganic. In addition, TCEQ data for 1,3-Butadiene, Nickel, Metallic, Nickel Oxide, Nickel Refinery Dust, and Nickel Subsulfide was previously added to the ITER PR column and has now been moved to the TCEQ column. TCEQ’s data for these chemicals is based on TCEQ’s Development Support Documents (DSD) for Nickel and Inorganic Nickel Compounds; 1,3-Butadiene; and Arsenic and Inorganic Arsenic Compounds.  
 
 
March 30, 2012 
 
U.S. EPA recently updated or added data on IRIS for Dioxin (2,3,7,8-TCDD), Hexachloroethane and Tetrahydrofuran. The ITER entries for Dioxin (2,3,7,8-TCDD), Hexachloroethane and Tetrahydrofuran have been updated based on IRIS, and include a link to the IRIS website.  

December 30, 2011 
 
We recently added data from NSF International for Diacetone Alcohol (DAA). The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of the document as well as a link to purchase the full report. Diacetone Alcohol is a new addition to ITER. 
 
We recently added data from NSF International for Di-2-ethylhexyl Terephthalate (DEHT), Dimethyl Terephthalate (DMT), and Terephthalic Acid (TPA). The ITER entries for these chemicals are based on a published manuscript, and include a link to the Executive Summary as well as a link to purchase the manuscript. The NSF International Health Advisory Board conducted an external peer review of these assessments prior to publication. Di-2-ethylhexyl Terephthalate (DEHT) and Terephthalic Acid (TPA) are new additions to ITER. 
 
U.S. EPA recently updated its data on IRIS for Dichloromethane and Trichlorothylene. The ITER entries for Dichloromethane (Methylene Chloride) and Trichloroethylene (TCE) have been updated based on IRIS, and include a link to the IRIS website.  
 
We recently added data from RIVM (The Netherlands) for Polycyclic Aromatic Hydrocarbons (PAHs). The ITER entries for these chemicals are based on the RIVM report, “Re-evaluation of human-toxicological Maximum Permissible Risk levels” (2001), and include a link to this report. 
 
August 18, 2011 
 
We recently added inhalation risk data from the Texas Commission on Environmental Quality (TCEQ) for Nickel, Metallic, Nickel Oxide, Nickel Refinery Dust, and Nickel Subsulfide. TCEQ’s data is located in the ITER PR (Peer Review) column for these chemicals, and is based on TCEQ’s Development Support Document (DSD) for Nickel and Inorganic Nickel Compounds. (TERA conducted an independent peer review of this assessment).  
 
TERA recently initiated the ITER Review Program – ITERate - to convene a panel of experts which evaluates the basis and derivation of risk values published in peer reviewed manuscripts and determines whether it is appropriate to load onto ITER. The second meeting resulted in loading the following data to ITER under the ITER PR column: Manganese Oxide (noncancer inhalation data from Bailey et al. 2009). Details about this review process and the meeting report can be found at https://tera.org/Peer/ITERReview/index.html. Manganese Oxide is a new addition to ITER.  
 
U.S. EPA recently added data to IRIS for Urea. The ITER entry for Urea has been added based on IRIS, and include a link to the IRIS website. 
 
July 15, 2011  
 
ATSDR published an Addendum to the Toxicological Profile for Manganese in September 2010. Based on comments received on its draft 2008 chronic inhalation minimal risk level, ATSDR has elected to retain its MRL that was derived in the 2000 Toxicological Profile until such time as the profile is finalized. The noncancer inhalation ITER entry for Manganese has been updated based on this Addendum.  
 
June 30, 2011  
 
ATSDR published an updated Toxicological Profile for Uranium in May 2011. The ITER entries for Uranium and Uranium, soluble salts have been updated based on the Toxicological Profiles. 
June 17, 2011  
 
EPA recently removed its reference dose (RfD) for Chlorpyrifos from the IRIS database. The ITER file for Chlorpyrifos has been updated to reflect this.  
 
April 29, 2011  
 
TERA recently initiated the ITER Review Program – ITERate - to convene a panel of experts which evaluates the basis and derivation of risk values published in peer reviewed manuscripts and determines whether it is appropriate to load onto ITER. The first meeting resulted in loading the following data to ITER under the ITER PR column: Acrylamide (cancer oral data from Dourson et al. 2008), Decabromodiphenyl Ether (DecaBDE) (noncancer oral data from Hardy et al. 2009), and Dioxin (2,3,7,8-TCDD) (cancer oral data from Simon et al., 2009). Details about this review process and the meeting report can be found at https://tera.org/Peer/ITERReview/index.html  
 
March 31, 2011 
 
We recently added data from RIVM (The Netherlands) for cis-1,2-Dichloroethylene and trans-1,2-dichloroethylene. The ITER entries for these chemicals are based on the RIVM report, “Re-evaluation of some human-toxicological Maximum Permissible Risk levels earlier evaluated in the period 1991-2001” (2008), and include a link to this report. 
 
February 8, 2011 
 
U.S. EPA recently revised it data on IRIS for Hydrogen Cyanide and Cyanide Salts, Pentachlorophenol, 1,1,2,2- Tetrachloroethane, and trans-1,2-Dichloroethylene. The ITER entries for Hydrogen Cyanide, Pentachlorophenol, 1,1,2,2- Tetrachloroethane, and trans-1,2-Dichloroethylene have been updated based on IRIS, and include a link to the IRIS website.  
 
We recently added cancer classifications from IARC for Pentachlorophenol. The ITER entry for this chemical is based on Volume 71of the IARC Monographs, and includes a link to the Monographs. 
 
We recently updated data from NSF International for 1,1,2,2- Tetrachloroethane. The ITER entry for this chemical is based on information contained in the NSF International drinking water standards NSF/ANSI 60 and 61, as NSF International adopts the US EPA IRIS oral slope factor for this chemical. 
 
We recently added data from NSF International for o-Toluidine and p-tert-Butylphenol. The ITER entries for these chemicals are based on the NSF International Oral Risk Assessment Documents, and include a link to the Executive Summary of the document as well as a link to purchase the full report. Both chemicals are new additions to ITER. 


January 27, 2011 
 
We recently added data from RIVM (The Netherlands) for di-n-octyltin (DOT), Tributyltin oxide (TBTO), and Triphenyltin (TPT). The ITER entries for these chemicals are based on the RIVM report, “Re-evaluation of human-toxicological Maximum Permissible Risk levels earlier evaluated in the period 1991-2001” (2009), and include a link to this report. Di-n-octyltin (DOT) and Triphenyltin (TPT) are new additions to ITER.  
 
U.S. EPA recently updated its data on IRIS for Trichloroacetic acid (TCA). The ITER entry for Trichloroacetic acid (TCA) has been updated based on IRIS, and includes a link to the IRIS website.  

December 31, 2010  
 
We recently added data from NSF International for Lanthanum Carbonate and Tetramethylsuccinonitrile. The ITER entries for these chemicals are based on the NSF International Oral Risk Assessment Documents, and include a link to the Executive Summary of the document as well as a link to purchase the full report. Both chemicals are new additions to ITER. 
 
We recently updated data from NSF International for 1,4-Dioxane. The ITER entry for this chemical is based on information contained in the NSF International drinking water standards NSF/ANSI 60 and 61, as NSF International adopts the US EPA IRIS reference dose (RfD) for these chemicals. 
 
U.S. EPA recently added new data to IRIS for Chloroprene and cis-1,2-Dichloroethylene. The ITER entries for Chloroprene and cis-1,2-Dichloroethylene have been added based on IRIS, and include a link to the IRIS website. Chloroprene is a new addition to ITER. 
 
U.S. EPA recently revised it data on IRIS for 1,4-Dioxane. The ITER entry for 1,4-Dioxane has been updated based on IRIS, and includes a link to the IRIS website.  
 
ATSDR published updated Toxicological Profiles for Boron, Chlorine, Ethylbenzene, Ethylene Glycol, Plutonium, and Styrene in November 2010. The ITER entries for Boron, Chlorine, Ethylbenzene, Ethylene Glycol, Plutonium, and Styrene have been updated based on the Toxicological Profiles. 
 
We recently added cancer classifications from IARC for 1,4-Dioxane, Ethylbenzene, and Styrene. The ITER entries for these chemicals are based on Volumes 71 (1,4-Dioxane), 77 (Ethylbenzene), and 82 (Styrene) of the IARC Monographs, and include a link to the Monographs. 
 
December 3, 2010 
 
We recently added data from NSF International for 1,2-Epoxybutane. The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of the document as well as a link to purchase the full report.  
 
We recently added data from RIVM (The Netherlands) for Ethyl-t-butyl ether (ETBE), and Vanadium, Vanadium Pentoxide . The ITER entries for these chemicals are based on the RIVM report, “Re-evaluation of some human-toxicological Maximum Permissible Risk levels earlier evaluated in the period 1991-2001” (2008), and include a link to this report. 
 
ATSDR published Draft for Public Comment Toxicological Profiles for Toxaphene and Trichlorobenzenes in September 2010. The ITER entries for Toxaphene, 1,2,3-Trichlorobenzene, 1,2,4-Trichlorobenzene, and 1,3,5-Trichlorobenzene have been updated based on the Toxicological Profiles. 
 
September 30, 2010  
 
We recently added data from RIVM (The Netherlands) for Antimony, Chloride, Sulfate, and Tin (Inorganic). The ITER entries for these chemicals are based on the RIVM report, “Re-evaluation of some human-toxicological Maximum Permissible Risk levels earlier evaluated in the period 1991-2001” (2008), and include a link to this report. 
 
ATSDR published a Draft for Public Comment Toxicological Profile for RDX in July 2010. The ITER entry for Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) has been updated based on the Toxicological Profile. 
 
September 10, 2010  
 
We recently added data from NSF International for Triallyl Isocyanurate. The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of the document as well as a link to purchase the full report. Triallyl Isocyanurate is a new addition to ITER. 
 
We recently added data from NSF International for Melamine. The ITER entry for this chemical is based on a published manuscript, and includes a link to the Executive Summary as well as a link to purchase the manuscript. The NSF International Health Advisory Board conducted an external peer review of this assessment prior to publication. Melamine is a new addition to ITER. 
 
We recently added cancer classifications from IARC for: 
• Anthracene 
• Arsenic, Inorganic  
• Azobenzene 
• 2,4- Benzo[g,h,i]perylene 
• Chlorodifluoromethane,  
• Ethyl Chloride (Chloroethane)  
• Chloromethyl Methyl Ether 
• d-Limonene 
• Diaminotoluene 
• 1,3 Dibromochloromethane (chlorodibromomethane) 
• Dichloropropene (Telone II) 
• 1,3-Dihydroxybenzene (Resorcinol) 
• Ethyl Carbamate (Urethane) 
• 4,4'-Methylenedianiline 
• Mineral-based Crankcase Oil (Crude Oil) 
• N,N- Dimethylformamide 
• Picloram 
• Propylene Oxide 
• Pydrin (Esfenvalerate) 
• Pyridine 
• Simazine 
 
The ITER entries for these chemicals are based on the IARC Monographs, and include a link to the Monographs.  
 
July 30, 2010 
 
We recently added cancer classifications from IARC for 1,3-Butadiene, Ethylene Oxide, Vinyl Bromide, Vinyl Chloride, and Vinyl Fluoride. The ITER entries for these chemicals are based on Volume 97 of the IARC Monographs, and include a link to the Monographs. Vinyl Fluoride is a new addition to ITER. 
 
We recently added cancer classifications from IARC for: 
• Acetaldehyde 
• Acrylamide 
• Antimony Trioxide 
• Aramite 
• Asbestos 
• Atrazine 
• Bromoform 
• Caprolactam 
• Carbon Tetrachloride 
• Chloroform (Trichloromethane) 
• Chloral Hydrate 
• Cobalt 
• Deltamethrin 
• Di(2-ethylhexyl)adipate 
• 1,4-Dichlorobenzene 
• 1,2-Dichloroethane 
• 1,2-Dichloropropane 
• 1,2-Epoxybutane 
• Ethylene Thiourea 
• Formaldehyde 
• Furan 
• Glycidaldehyde 
• Hexachlorobenzene 
• Hexachloroethane 
• Hydrazine 
• 4,4'-Methylenebis(2-chloroaniline) (MBOCA) 
• Methylene diphenyl diisocyanate 
• Trichloroacetic Acid 
• 1,2,3-Trichloropropane 
• Trifluralin 
• 2,4,6-Trinitrotoluene 
• 1,1-Dichloroethylene (Vinylidene Chloride)  
 
The ITER entries for these chemicals are based on the IARC Monographs, and include a link to the Monographs.  
 
 
June 15, 2010 
 
We recently added inhalation risk data from the Texas Commission on Environmental Quality (TCEQ) for 1,3-Butadiene. TCEQ’s data is located in the ITER PR (Peer Review) column for this chemical, and is based on TCEQ’s Development Support Document (DSD) for 1,3- Butadiene. (TERA conducted an independent peer review of this assessment).  
 
 
May 27, 2010 
 
U.S. EPA recently revised it data on IRIS for Acrylamide, Carbon Tetrachloride, and Ethylene glycol monobutyl ether (EGBE). The ITER entries for Acrylamide, Carbon Tetrachloride, and 2-Butoxyethanol (EGBE) have been updated based on IRIS, and include links to the IRIS website.  
 
We recently updated data from NSF International for 2-Butoxyethanol (EGBE) . The ITER entry for this chemical is based on information contained in the NSF International drinking water standards NSF/ANSI 60 and 61, as NSF International adopts the US EPA IRIS reference dose (RfD) for these chemicals. 
 
March 10, 2010 
 
We recently added data from NSF International for 2,6-Dichloro-1,4-Benzenediamine and 4,4’-Methylenedianiline. The ITER entries for these chemicals are based on the NSF International Oral Risk Assessment Documents, and include a link to the Executive Summary of the documents as well as a link to purchase the full reports. 
 
U.S. EPA recently revised it data on IRIS for Thallium, Thallium Oxide, and Thallium Selenite. The ITER entries for Thallium, Thallium Oxide (formerly called Thallic Oxide), and Thallium Selenite have been updated based on IRIS, and include links to the IRIS website. The Thallium assessment replaces the assessments for the following related substances (which have subsequently been removed from ITER as well): 
 
Thallium acetate 
• Thallium carbonate 
• Thallium chloride 
• Thallium nitrate 
• Thallium (I) sulfate 
 
ATSDR published a Draft for Public Comment Toxicological Profile for Phosphate Ester Flame Retardants in September 2009. The ITER entries for Tributoxyethyl phosphate (TBEP), Tri-(2-chloroethyl) phosphate (TCEP), Tributyl phosphate (TnBP), Tris(1,3-dichloro-2-propyl) phosphate (TDCP), Triisobutyl phosphate (TiBP), Triphenyl phosphate (TPP), Tri-(2-chloroisopropyl) phosphate (TCPP), have been added based on the Toxicological Profiles. All seven of these chemicals are new additions to ITER. 
 
ATSDR published a Draft for Public Comment Toxicological Profile for Perfluoroalkyls in May 2009. The ITER entry for Perfluoroalkyls has been added based on the Toxicological Profile. Perfluoroalkyls is a new addition to ITER. 
December 31, 2009 
 
U.S. EPA recently added new data to IRIS for Bromobenzene, Cerium Oxide and Cerium Compounds, and Chlordecone (Kepone). The ITER entries for Bromobenzene, Cerium Oxide and Cerium Compounds, and Chlordecone (Kepone) have been added based on IRIS, and include a link to the IRIS website. Bromobenzene and Cerium Oxide and Cerium Compounds are new additions to ITER.  
U.S. EPA recently revised its data on IRIS for 2-Hexanone and 1,2,3-Trichloropropane. The ITER entries for 2-Hexanone and 1,2,3-Trichloropropane have been updated based on IRIS, and includes links to the IRIS website.  
 
ATSDR published Draft for Public Comment Toxicological Profiles for Acrylamide, 1,3-Butadiene, Carbon Monoxide, and Vanadium in September 2009. The ITER entries for Acrylamide, 1,3-Butadiene, Carbon Monoxide, Vanadium, and Vanadium Pentoxide have been updated based on the Toxicological Profiles. Carbon Monoxide is a new addition to ITER. 
 
March 30, 2009 
 
ATSDR published Draft for Public Comment Toxicological Profiles for Cadmium, Chromium, and Manganese in September 2008. The ITER entries for Cadmium, Chromium (III), chromic ion, Chromium (VI), hexavalent, and Manganese have been updated based on the Toxicological Profiles. 
 
ATSDR published updated Toxicological Profiles for Aluminum, Cresols, Diazinon, Dichloropropenes, Guthion, Perchlorates, Phenol, and 1,1,2,2-Tetrachloroethane in September 2008. The ITER entries for Aluminum, Ammonium Perchlorate, Diazinon, 1,1-Dichloropropene, 1,2-Dichloropropene, 1,3-Dichloropropene (Telone II), 2,3- Dichloropropene, 3,3-Dichloropropene, Guthion, 2-Methylphenol (o-cresol), 3-Methylphenol (m-cresol), 4-Methylphenol (p-cresol), Phenol, 1,1,2,2-Tetrachloroethane, and Tricresol have been updated based on the Toxicological Profiles. 1,1-Dichloropropene, 1,2-Dichloropropene, 2,3- Dichloropropene, and 3,3-Dichloropropene are new additions to ITER. 
 
February 12, 2009 
 
We recently added data from NSF International for Diethanolamine, 2-Ethylhexanoic Acid, and 2-Ethylhexanol. The ITER entries for these chemicals are based on the NSF International Oral Risk Assessment Documents, and include a link to the Executive Summary of these documents as well as a link to purchase the full report. Diethanolamine, 2-Ethylhexanoic Acid, and 2-Ethylhexanol are new additions to ITER.  
 
U.S. EPA recently added new data to IRIS for Propionaldehyde. The ITER entry for Propionaldehyde has been added based on IRIS, and includes a link to the IRIS website. Propionaldehyde is a new addition to ITER.  
 
U.S. EPA recently revised it data on IRIS for Nitrobenzene. The ITER entry for Nitrobenzene has been updated based on IRIS, and includes links to the IRIS website.  
December 11, 2008 
 
We recently added data from NSF International for Ethanolamine. The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of this document as well as a link to purchase the full report. 
 
ATSDR published a Draft for Public Comment Toxicological Profile for Radon in September 2008. The ITER entry for Radon has been updated based on the Toxicological Profile. 
 
September 8, 2008 
 
We recently launched a new database that is a companion to ITER called the Risk Information Exchange (RiskIE). Explore RiskIE at https://www.allianceforrisk.org/RiskIE.htm.  
 
We recently published a manuscript about our ITER and RiskIE (Risk Information Exchange) databases: Wullenweber, A., et al. 2008. Resources for global risk assessment: The International Toxicity Estimates for Risk (ITER) and Risk Information Exchange (RiskIE) databases. Toxicol. Appl. Pharmacol. doi:10.1016/j.taap.2007.12.035 
 
U.S. EPA recently added new data to IRIS for 2,2’,4,4’,5,5’-Hexabromodiphenyl Ether (BDE-153), 2,2',4,4',5-Pentabromodiphenyl Ether (BDE-99), and 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47). ITER entries for 2',4,4',5,5'- Hexabromodiphenyl ether (BDE-153), 2,2',4,4',5-Pentabromodiphenyl Ether (BDE-99), and 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) have been added based on IRIS, and include links to the IRIS website. 2,2’,4,4’,5,5’-Hexabromodiphenyl Ether (BDE-153), 2,2',4,4',5-Pentabromodiphenyl Ether (BDE-99), and 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) are new additions to ITER. 
 
U.S. EPA recently revised it data on IRIS for Decabromodiphenyl Ether (DecaBDE). The ITER entry for Decabromodiphenyl Ether (DecaBDE) has been updated based on IRIS, and include links to the IRIS website.  
 
ATSDR published updated an updated Toxicological Profile for Cyanide in July 2006. The ITER entries for Calcium Cyanide, Copper Cyanide, Cyanide, free, Cyanogen, Cyanogen Chloride (Chlorine Cyanide), Hydrogen Cyanide, Potassium Cyanide, Potassium Silver Cyanide, Sodium Cyanide, and Zinc Cyanide have been updated based on the Toxicological Profile.  
 
May 8, 2008 
 
ATSDR published Toxicological Profiles for Ethylbenzene, Ethylene Glycol, and Styrene in September 2007. The ITER entries for Ethylbenzene, Ethylene Glycol, and Styrene have been updated based on the Toxicological Profiles.  
 
March 31, 2008 
 
ATSDR published Draft for Public Comment Toxicological Profiles for Boron, Chlorine, and Plutonium in September 2007. The ITER entries for Boron, Chlorine, and Plutonium have been updated based on the Toxicological Profiles.  
 
ATSDR published updated Toxicological Profiles for Acrolein, Barium, Benzene, Lead, and Xylenes in August 2007. The ITER entries for Acrolein, Barium, Benzene, Lead and Compounds, and Xyleneshave been updated based on the Toxicological Profiles.  
 
We recently added cancer classifications from IARC for Cyclohexanone, 2-Nitropropane, Propyleneimine (2-Methylaziridine), 1,1,1,2-Tetrachloroethane, 1,1,2,2-Tetrachloroethane, and 1,1,1-Trichloroethane. The ITER entries for these chemicals are based on the IARC Monographs, and include a link to the Monographs.  
 
January 14, 2008 
 
We recently added data from NSF International for Ethylene Diamine. The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of this document as well as a link to purchase the full report.  
December 18, 2007 
 
We recently added data from NSF International for Triethanolamine. The ITER entry for this chemical is based on the NSF International Oral Risk Assessment Document, and includes a link to the Executive Summary of this document as well as a link to purchase the full report. Triethanolamine is a new addition to ITER.  
 
ATSDR published updated Toxicological Profiles for Arsenic and Heptachlor & Heptachlor Epoxide in August 2007. The ITER entries for Arsenic, Cacodylic Acid (Dimethylarsinic Acid, DMA), Heptachlor, Heptachlor Epoxide, Monomethylarsonic Acid (MMA), and Roxarsone have been updated based on the Toxicological Profiles. Monomethylarsonic Acid (MMA) and Roxarsone are new additions to ITER. 
 
ATSDR published an updated Toxicological Profile Dichlorobenzenes in August 2006. The ITER entries for 1,2-Dichlorobenzene, 1,3-Dichlorobenzene, 1,4-Dichlorobenzene have been updated based on the Toxicological Profile. 
 
ATSDR published Toxicological Profiles for Hydrogen Sulfide, 1,1,1-Trichloroethane, Vinyl Chloride in July 2006. The ITER entries for Hydrogen Sulfide, 1,1,1-Trichloroethane, Vinyl Chloride have been updated based on the Toxicological Profiles.  
 
October 12, 2007 
 
U.S. EPA recently revised it data on IRIS for 1,1,1-Trichloroethane and 2,2,4-Trimethylpentane. The ITER entries for 1,1,1-Trichloroethane and 2,2,4-Trimethylpentane have been updated based on IRIS, and include links to the IRIS website.  
 
May 25, 2007  
 
ATSDR published an updated Toxicological Profile for 1,4-Dioxane in April 2007. The ITER entry for 1,4 – Dioxane has been updated based on the Toxicological Profile.  
 
April 26, 2007 
 
We recently added data from the US Army Center for Health Promotion and Preventive Medicine (CHPPM) for six chemical warfare agents: Lewisite, Sarin (GB), Soman (GD), Sulfur Mustard (HD), Tabun (GA), and VX. This data underwent peer review by the National Research Council (NRC), and is located under the IPRV column on ITER. Lewisite, Sarin (GB), Soman (GD), Tabun (GA), and VX are new additions to ITER.  
 
April 12, 2007 
 
NEW COLUMN ADDED!  
 
We recently added a new column to ITER, entitled “IPRV – Independently Peer Reviewed Values”. The IPRV column contains data from those organizations that do not meet the criteria for having their own column (such as having data for at least 40 chemicals) and whose risk values have undergone peer review outside TERA’s ITER Peer Review process. In addition, we changed the existing column name “ITER” to “ITER PR”. The ITER PR column contains data from those organizations whose risk values have undergone peer review through TERA’s ITER Peer Review process (https://tera.org/peer). This independent peer review is convened by TERA through its Peer Review Program, and if the expert panel concurs with an assessment, it can be made available to the public on the ITER database. These independent values can only be found on ITER.